Determination of the effect of the release of methotrexate from an in situ forming implant on colon carcinoma cells and in vivo studies in the rat model

  • Ameena Wadee University of the Witwatersrand
  • Viness Pillay University of the Witwatersrand
  • Yahya E Choonara University of the Witwatersrand
  • Lisa C du Toit University of the Witwatersrand
  • Pradeep Kumar University of the Witwatersrand
  • Clement Penny University of the Witwatersrand
  • Leith Meyer University of the Witwatersrand
Keywords: methotrexate, colon carcinoma cells

Abstract

Despite advances in cancer therapy, the successful treatment of solid tumours remains difficult, as there are numerous barriers to treatment that must be overcome.1 Among these barriers are physiological barriers, such as diffusion of the drug from the bloodstream through the tumour, as well as patient tolerability to the typically high doses required for the treatment of solid tumours. One solution to this problem is the development of novel drugs for the treatment of cancer. However, the time taken for the launch of a novel compound, from development stage to the patient, is long, and the expense of such development is considerable. Another simpler solution to the treatment of solid tumours is to investigate approaches to deliver existing drugs, so that current problems faced are overcome. Hence the focus has shifted to targeted drug delivery systems.2

Author Biographies

Ameena Wadee, University of the Witwatersrand
Department of Pharmacy and Pharmacology Wits Advanced Drug Delivery Platform University of the Witwatersrand
Viness Pillay, University of the Witwatersrand
Department of Pharmacy and Pharmacology Wits Advanced Drug Delivery Platform University of the Witwatersrand
Yahya E Choonara, University of the Witwatersrand
Department of Pharmacy and Pharmacology Wits Advanced Drug Delivery Platform University of the Witwatersrand
Lisa C du Toit, University of the Witwatersrand
Department of Pharmacy and Pharmacology Wits Advanced Drug Delivery Platform University of the Witwatersrand
Pradeep Kumar, University of the Witwatersrand
Department of Pharmacy and Pharmacology Wits Advanced Drug Delivery Platform University of the Witwatersrand
Clement Penny, University of the Witwatersrand
Department of Medical Oncology University of the Witwatersrand
Leith Meyer, University of the Witwatersrand
Central Animal Service University of the Witwatersrand
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Cum Laude