Surfactant directed synthesis and self-assembly of geometric cytotoxic copper nanocrystals

  • Karmani Murugan University of the Witwatersrand
  • Yahya E Choonara University of the Witwatersrand
  • Pradeep Kumar University of the Witwatersrand
  • Lisa C Du Toit University of the Witwatersrand
  • Viness Pillay University of the Witwatersrand
Keywords: geometric cytotoxic copper nanocrystals, surfactant directed synthesis, self-assembly

Abstract

The versatility of copper nanoparticles (CuNPs) facilitates its biomedical applications as a cytotoxic agent via oxidative stress, exerts antibacterial activity, functions as an in vivo agent for imaging as well as for advanced drug delivery applications.1,2 In the last decade, researchers have proven that by manipulating the physicochemical, physicomechanical and morphological properties of CuNPs its application expands. In particular, the geometrical shape of CuNPs has gained much interest. By further controlling the shape of CuNPs, cellular internalisation can be dictated thereby enhancing copper delivery into target cells. The self-assembly control process is able to maintain the nanoshape within the colloidal dispersion by minimal chemical, physical or mechanical modification during synthesis, however, despite advances it is still highly complex to optimise the shape of CuNPs. This study focused on the novel synthesis of CuNPs of four different geometries by manipulating surfactant concentrations with homogeneity throughout each colloidal solution.

Author Biographies

Karmani Murugan, University of the Witwatersrand
Wits Advanced Drug Delivery Platform Research Unit Department of Pharmacy and Pharmacology School of Therapeutic Sciences Faculty of Health Sciences University of the Witwatersrand
Yahya E Choonara, University of the Witwatersrand
Wits Advanced Drug Delivery Platform Research Unit Department of Pharmacy and Pharmacology School of Therapeutic Sciences Faculty of Health Sciences University of the Witwatersrand
Pradeep Kumar, University of the Witwatersrand
Wits Advanced Drug Delivery Platform Research Unit Department of Pharmacy and Pharmacology School of Therapeutic Sciences Faculty of Health Sciences University of the Witwatersrand
Lisa C Du Toit, University of the Witwatersrand
Wits Advanced Drug Delivery Platform Research Unit Department of Pharmacy and Pharmacology School of Therapeutic Sciences Faculty of Health Sciences University of the Witwatersrand
Viness Pillay, University of the Witwatersrand
Wits Advanced Drug Delivery Platform Research Unit Department of Pharmacy and Pharmacology School of Therapeutic Sciences Faculty of Health Sciences University of the Witwatersrand
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