Psoriasis

  • Deirdre Engler Sefako Makgatho Health Sciences University
  • Hiskiah Percy Chezuba Institute of Health Sciences
  • Palesa Masuku Sefako Makgatho Health Sciences University
Keywords: Psoriasis, immune-mediated, keratinocytes, comorbidities, pro-inflammatory mediators, cytokines

Abstract

Psoriasis is a non-communicable, complex and multifactorial disease that cannot be cured. It is an immune-mediated, genetic disease manifesting in the skin or joints or both. Psoriasis is mainly a dendritic and T-cell-mediated disease with complex feedback loops. Dysregulated interactions between the innate and adaptive immune system results in psoriatic skin lesions that can cause visible disfiguration. It subsequently has a negative impact on patients’ psychosocial status and quality of life. Co-morbidities including psoriatic arthritis, cardiovascular disease and metabolic syndrome increase the huge burden of the disease. Treatment of psoriasis has evolved with the understanding of the pathogenesis of this chronic condition, leading to more targeted therapy.

Author Biographies

Deirdre Engler, Sefako Makgatho Health Sciences University
BPharm, BScHons (Pharmacology), MScMed (Clinical Pharmacy) School of Pharmacy Faculty of Health Sciences Sefako Makgatho Health Sciences University
Hiskiah Percy Chezuba, Institute of Health Sciences
BPharm, Masters candidate (Masters in Pharmacy) Head of Department Pharmacy Department Institute of Health Sciences Molepolole Botswana
Palesa Masuku, Sefako Makgatho Health Sciences University
Academic Intern (Masters in Pharmacy) School of Pharmacy Faculty of Health Sciences Sefako Makgatho Health Sciences University
Published
2017-09-18
Section
Reviews