Fungal infections – An overview

  • Natalie Schellack Sefako Makgatho Health Sciences University
  • Jade Du Toit Sefako Makgatho Health Sciences University
  • Tumelo Mokoena Sefako Makgatho Health Sciences University
  • Elmien Bronkhorst Sefako Makgatho Health Sciences University
Keywords: Invasive fungal diseases, superficial fungal diseases, fungal skin infections

Abstract

Fungi normally originate from the environment that surrounds us, and appear to be harmless until inhaled or ingestion of spores occurs. A pathogenic fungus may lead to infection. People who are at risk of acquiring fungal infection are those living with human immunodeficiency virus (HIV), cancer, receiving immunosuppressant therapy, neonates and those of advanced age. The management of superficial fungal infections is mainly topical, with agents including terbinafine, miconazole and ketoconazole. Oral treatment includes griseofulvin and fluconazole. Invasive fungal infections are difficult to treat, and are managed with agents including the azoles, echinocandins and amphotericin B. This paper provides a general overview of the management of fungus infections.

Author Biographies

Natalie Schellack, Sefako Makgatho Health Sciences University
BCur, BPharm, PhD (Pharmacy) Associate Professor Department of Pharmacy Faculty of Health Sciences Sefako Makgatho Health Sciences University
Jade Du Toit, Sefako Makgatho Health Sciences University
BPharm School of Pharmacy Faculty of Health Sciences Sefako Makgatho Health Sciences University
Tumelo Mokoena, Sefako Makgatho Health Sciences University
BPharm School of Pharmacy Faculty of Health Sciences Sefako Makgatho Health Sciences University
Elmien Bronkhorst, Sefako Makgatho Health Sciences University
BPharm, MSc(Med) School of Pharmacy Faculty of Health Sciences Sefako Makgatho Health Sciences University
Published
2019-03-01
Section
Reviews