Vitamin B-complex deficiency, supplementation and management

  • Gustav Schellack
  • Pamela Harirari Sefako Makgatho Health Sciences University
  • Natalie Schellack Sefako Makgatho Health Sciences University
Keywords: vitamin B, B-complex vitamins, thiamine, riboflavin, niacin, pyridoxine, pantothenic acid, biotin, inositol, folic acid, folate, cobalamin, Wernicke-Korsakoff syndrome, beriberi, pellagra, pernicious anaemia, megaloblastic anaemia, intrinsic factor, haematinic, peripheral neuropathy

Abstract

Vitamins are either fat-soluble or water-soluble micronutrients that are derived from a healthy, well-balanced diet. The B-complex vitamins are well-known examples of such water-soluble nutrients that are readily absorbed from a healthy gut, and easily eliminated via renal excretion. They are required for their vital physiological functions and are significant contributors towards maintaining optimal health. Multiple B-vitamin deficiencies are quite commonly seen and therefore a balanced diet, including a full spectrum of B-vitamins, is usually needed when any of them is found to be deficient. Conversely, their therapeutic value will be limited to supplementation during states of deficiency, since they have no additional benefits in the presence of an adequate dietary intake. In general, their active supplementation should only be used to correct deficiencies. This article provides an overview of such B-complex vitamin deficiencies and their supplementation.

Author Biographies

Gustav Schellack
Pharmaceutical Industry (Clinical Research)
Pamela Harirari, Sefako Makgatho Health Sciences University
Department of Pharmacy, Faculty of Health Sciences, Sefako Makgatho Health Sciences University
Natalie Schellack, Sefako Makgatho Health Sciences University
BCur, BPharm, PhD (Pharmacy), Associate Professor, Department of Pharmacy, Faculty of Health Sciences, Sefako Makgatho Health Sciences University
Published
2019-04-29
Section
Reviews