Bisphosphonate medicine use in the management of osteoporosis

  • Natalie Schellack Sefako Makgatho Health Sciences University
  • K Mogale Sefako Makgatho Health Sciences University
  • L Wadesango Sefako Makgatho Health Sciences University
  • N Nxumalo Sefako Makgatho Health Sciences University
Keywords: osteoporosis, Biphosphonates

Abstract

Osteoporosis is a common systemic progressive skeletal disease that remains a significant problem worldwide. It is important to understand the pathogenesis and the possible mechanism of action of anti-osteoporotic drugs. Treatment of osteoporosis is strictly related to severity of pathology and consists of prevention of fragility fractures with the correct lifestyle and adequate nutritional supplements. Bisphosphonates are the agents most extensively studied and prescribed in clinical practice for more than 20 years. They give the most effective protection from various fractures including vertebral, hip and other non-vertebral fractures. Bisphosphonates are generally well tolerated and have a favourable safety profile when used in the treatment of osteoporosis. This review aims to provide an overview of the management of osteoporosis with the use of bisphosphonate medicines. The purpose of this review is to focus on the main current pharmacological products available for the treatment of osteoporotic patients.

Author Biographies

Natalie Schellack, Sefako Makgatho Health Sciences University

BCur, BPharm, PhD (Pharmacy) Associate Professor, Department of Pharmacy, Faculty of Health Sciences, Sefako Makgatho Health Sciences University

K Mogale, Sefako Makgatho Health Sciences University

BPharm, Academic Intern, School of Pharmacy, Faculty of Health Sciences, Sefako Makgatho Health Sciences University

L Wadesango, Sefako Makgatho Health Sciences University

BPharm, Academic Intern, School of Pharmacy, Faculty of Health Sciences, Sefako Makgatho Health Sciences University

N Nxumalo, Sefako Makgatho Health Sciences University

BPharm, Academic Intern, School of Pharmacy, Faculty of Health Sciences, Sefako Makgatho Health Sciences University

Published
2019-05-10
Section
Reviews