Gastro-oesophageal reflux disease: a pharmacist’s perspective for 2020

  • N Schellack Sefako Makgatho Health Sciences University
  • G Schellack
  • J C Meyer Sefako Makgatho Health Sciences University
  • L Malan Sefako Makgatho Health Sciences University
  • Q Labuschagne Sefako Makgatho Health Sciences University
  • N Nxumalo Sefako Makgatho Health Sciences University
  • K Kupa Sefako Makgatho Health Sciences University
Keywords: GORD, gastro-oesophageal reflux disease, PPIs, proton-pump inhibitors, histamine-2 receptor antagonists, cytoprotective agents

Abstract

Gastro-oesophageal reflux disease (GORD) produces symptoms that cause great irritation and discomfort to the patient. Pharmacotherapeutic management is directed at minimising these symptoms and reducing the causative factors, e.g. acid production, thereby providing the necessary relief. Currently available agents include simple antacids and acid suppression therapy, including histamine-2 receptor antagonists, proton-pump inhibitors, mucosal or cytoprotective agents and pro-motility agents. Deciding on appropriate therapy will be dependent upon the diagnosis, side-effects and cost-effectiveness of the treatment.

Author Biographies

N Schellack, Sefako Makgatho Health Sciences University

Department of Pharmacy, Faculty of Health Sciences, Sefako Makgatho Health Sciences University, South Africa

G Schellack

Pharmaceutical Industry Specialist (Clinical Research), South Africa

J C Meyer, Sefako Makgatho Health Sciences University

Department of Pharmacy, Faculty of Health Sciences, Sefako Makgatho Health Sciences University, South Africa

L Malan, Sefako Makgatho Health Sciences University

Department of Pharmacy, Faculty of Health Sciences, Sefako Makgatho Health Sciences University, South Africa

Q Labuschagne, Sefako Makgatho Health Sciences University

Department of Pharmacy, Faculty of Health Sciences, Sefako Makgatho Health Sciences University, South Africa

N Nxumalo, Sefako Makgatho Health Sciences University

Department of Pharmacy, Faculty of Health Sciences, Sefako Makgatho Health Sciences University, South Africa

K Kupa, Sefako Makgatho Health Sciences University

Department of Pharmacy, Faculty of Health Sciences, Sefako Makgatho Health Sciences University, South Africa

Published
2020-07-08
Section
Reviews