Young Scientist Award 2007
AbstractThe blood brain barrier (BBB) proves a major obstacle for drug delivery to the CNS and with only 1% of drugs able to penetrate the BBB, effective treatment for disorders such as Parkinson’s Disease (PD) is needed. Current therapy available for the treatment of PD gives rise to numerous side-effects and lack prolonged efficacy. A nano-enabled polymeric device implanted into the subarachnoid cavity of the brain may circumvent these challenges as drug is targeted to the affected areas of the brain and therefore a lower effective dose is required. The major benefit of an implantable device will be sustained release of drug which is imperative to prevent the ‘end-of-dose wearing-off’ phenomenon. The device will prove superior in that it serves to overcome the major barriers of current drug delivery systems available for the treatment of PD.
By submitting manuscripts to SAPJ, authors of original articles are assigning copyright to Medpharm Publications (Pty) Ltd. Authors may use their own work after publication without written permission, provided they acknowledge the original source. Individuals and academic institutions may freely copy and distribute articles published in SAPJ for educational and research purposes without obtaining permission.